ESQUIZOFRENIA
Enviado por Lisvilyu93 • 11 de Agosto de 2014 • 353 Palabras (2 Páginas) • 321 Visitas
Systemic lupus erythematosus (SLE) is a prototypic
autoimmune disease that affects more than 300,000
people in the US (1) and millions of people worldwide.
To ensure that there is a consistent definition of SLE for
the purposes of research and surveillance, classification
criteria for SLE are needed. The most widely used
classification criteria for SLE are those developed by the
American College of Rheumatology (ACR). These classification
criteria were published in 1982 (2) and were
revised by a committee in 1997 (3); according to the
revision, the item “positive LE preparation” was deleted,
and the criteria for an immunologic disorder were
changed to include anticardiolipin antibodies. The 1982
ACR criteria have been validated (4,5), but the 1997
revised criteria have not been validated.
Subsequently, multiple groups of investigators
used new statistical methodology to refine the criteria
for classification of SLE. Clough et al applied Bayes
theorem to data from patient and control populations
from the rheumatology department at the Cleveland
Clinic to develop weighted criteria for the diagnosis of
SLE (6). Costenbader et al formulated the Boston
Weighted Criteria system for the classification of SLE,
which was based on the Cleveland Clinic criteria but
included antiphospholipid antibodies (aPL) and renal
pathology (7). In addition, elements that might negate
the diagnosis, such as negative antinuclear antibodies
(ANAs), were subtracted from the criteria set. Some
criteria definitions were revised, such as arthritis requiring
an objective assessment of synovitis (7). The
weighted criteria were applied by Sanchez et al and were
shown to be more sensitive but less specific than the
ACR criteria (8).
An alternative
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