Presentation of the book "Theml, Color Atlas of Hematology"

i

Theml, Color Atlas of Hematology © 2004 Thieme

All rights reserved. Usage subject to terms and conditions of license.

ii

Theml, Color Atlas of Hematology © 2004 Thieme

All rights reserved. Usage subject to terms and conditions of license.

iii

Color Atlas ofHematology

PracticalMicroscopic and Clinical Diagnosis

Harald Theml,M.D.

Professor, Private Practice

Hematology/Oncology

Munich, Germany

Heinz Diem,M.D.

KlinikumGrosshadern

Institute of Clinical Chemistry

Munich, Germany

Torsten Haferlach,M.D.

Professor, KlinikumGrosshadern

Laboratory for Leukemia Diagnostics

Munich, Germany

2nd revised edition

262 color illustrations

32 tables

Thieme

Stuttgart · New York

Theml, Color Atlas of Hematology © 2004 Thieme

All rights reserved. Usage subject to terms and conditions of license.

iv

Library of Congress Cataloging-in-Publication

Data is available from the publisher

Important note: Medicine is an everchanging

science undergoing continual

development. Research and clinical experience

are continually expanding our

knowledge, in particular our knowledge of

proper treatment and drug therapy. Insofar

as this book mentions any dosage or application,

readers may rest assured that the

authors, editors, and publishers have made

every effort to ensure that such references

are in accordance with the state of knowledge

at the time of production of the

book.

Nevertheless, this does not involve, imply,

or express any guarantee or responsibility

on the part of the publishers in respect to

any dosage instructions and forms of applications

stated in the book. Every user is requested

to examine carefully the manufacturers’

leaflets accompanying each drug

and to check, if necessary in consultation

with a physician or specialist, whether the

dosage schedules mentioned therein or the

contraindications stated by the manufacturers

differ from the statements made in

the present book. Such examination is particularly

important with drugs that are

either rarely used or have been newly released

on the market. Every dosage

schedule or every form of application used

is entirely at the user’s own risk and responsibility.

The authors and publishers request

every user to report to the publishers

any discrepancies or inaccuracies noticed.

Some of the product names, patents, and

registered designs referred to in this book

are in fact registered trademarks or proprietary

names even though specific reference

to this fact is not always made in the

text. Therefore, the appearance of a name

without designation as proprietary is not to

be construed as a representation by the

publisher that it is in the public domain.

This book, including all parts thereof, is legally

protected by copyright. Any use, exploitation,

or commercialization outside

the narrow limits set by copyright legislation,

without the publisher’s consent, is illegal

and liable to prosecution. This applies in

particular to photostat reproduction, copying,

mimeographing, preparation of microfilms,

and electronic data processing and

storage.

This book is an authorized revised

translation of the 5th German edition

published and copyrighted 2002 by

Thieme Verlag, Stuttgart, Germany.

Title of the German edition:

Taschenatlas der Hämatologie

Translator: Ursula Peter-Czichi PhD,

Atlanta, GA, USA

1st German edition 1983

2nd German edition 1986

3rd German edition 1991

4th German edition 1998

5th German edition 2002

1st English edition 1985

1st French edition 1985

2nd French edition 2000

1st Indonesion edition 1989

1st Italian edition 1984

1st Japanese edition 1997

! 2004 Georg Thieme Verlag

Rüdigerstraße 14, 70469 Stuttgart,

Germany

http://www.thieme.de

Thieme New York, 333 Seventh Avenue,

New York, NY 10001 USA

http://www.thieme.com

Cover design: Cyclus, Stuttgart

Typesetting and printing in Germany by

Druckhaus Götz GmbH, Ludwigsburg

ISBN 3-13-673102-6 (GTV)

ISBN 1-58890-193-9 (TNY) 1 2 3 4 5

Theml, Color Atlas of Hematology © 2004 Thieme

All rights reserved. Usage subject to terms and conditions of license.

v

Preface

Our Current Edition

Although this is the second English edition of our hematology atlas, this

edition is completely new. As an immediate sign of this change, there are

now three authors. The completely updated visual presentation uses digital

images, and the content is organized according to the most up-to-date

morphological classification criteria.

In this new edition, our newly formed team of authors from Munich

(the “Munich Group”) has successfully shared their knowledge with you.

Heinz Diem and Torsten Haferlach are nationally recognized as lecturers

of the diagnostics curriculum of the German Association for Hematology

and Oncology.

Goals

Most physicians are fundamentally “visually oriented.” Apart from immediate

patient care, the microscopic analysis of blood plays to this preference.

This explains the delight and level of involvement on the part of

practitioners in the pursuit of morphological analyses.

Specialization notwithstanding, the hematologist wants to preserve

the opportunity to perform groundbreaking diagnostics in hematology for

the general practitioner, surgeon, pediatrician, the MTA technician, and all

medical support personnel. New colleagues must also be won to the

cause. Utmost attention to the analysis of hematological changes is essential

for a timely diagnosis.

Even before bone marrow cytology, cytochemistry, or immunocytochemistry,

information based on the analysis of blood is of immediate relevance

in the doctor’s office. It is central to the diagnosis of the diseases of

the blood cell systems themselves, which make their presence known

through changes in blood components.

The exhaustive quantitative and qualitative use of hematological diagnostics

is crucial. Discussions with colleagues from all specialties and

teaching experience with advanced medical students confirm its importance.

In cases where a diagnosis remains elusive, the awareness of the

next diagnostic step becomes relevant. Then, further investigation

through bone marrow, lymph node, or organ tissue cytology can yield firm

results. This pocket atlas offers the basic knowledge for the use of these

techniques as well.

Theml, Color Atlas of Hematology © 2004 Thieme

All rights reserved. Usage subject to terms and conditions of license.

vi

Organization

Reflecting our goals, the inductive organization proceeds from simple to

specialized diagnostics. By design, we subordinated the description of the

bone marrow cytology to the diagnostic blood analysis (CBC). However,

we have responded to feedback from readers of the previous editions and

have included the principles of bone marrow diagnostics and nonambiguous

clinical bone marrow findings so that frequent and relevant

diagnoses can be quickly made, understood, or replicated.

The nosology and differential diagnosis of hematological diseases are

presented to you in a tabular form.We wanted to offer you a pocketbook

for everyday work, not a reference book. Therefore, morphological curiosities,

or anomalies, are absent in favor of a practical approach to morphology.

The cellular components of organ biopsies and exudates are

briefly discussed, mostly as a reminder of the importance of these tests.

The images are consistently photographed as they normally appear in

microscopy (magnification 100 or 63 with oil immersion lens, occasionally

master-detail magnification objective 10 or 20). Even though

surprising perspectives sometimes result from viewing cells at a higher

magnification, the downside is that this by nomeans facilitates the recognition

of cells using your own microscope.

Instructions for the Use of this Atlas

The organization of this atlas supports a systematic approach to the study

of hematology (see Table of Contents). The index offers ways to answer

detailed questions and access the hematological terminology with references

to the main description and further citations.

The bestway to become familiar with your pocket atlas is to first have a

cursory look through its entire content. The images are accompanied by

short legends. On the pages opposite the images youwill find corresponding

short descriptive texts and tables. This text portion describes cell phenomena

and discusses in more detail further diagnostic steps as well as

the diagnostic approach to disease

...