Solventes
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Inhal Toxicol. 2012 Jun;24(7):434-8. doi: 10.3109/08958378.2012.684364.
Clinical presentation and management in acute toluene intoxication: a case series.
Cámara-Lemarroy CR, Gónzalez-Moreno EI, Rodriguez-Gutierrez R, González-González JG.
Source
Departamento de Medicina Interna. Hospital Universitario Dr. José E. González, Universidad Autónoma de Nuevo León, Madero y Gonzalitos S/N, Monterrey, Nuevo León 64460, México. crcamara83@hotmail.com
Abstract
CONTEXT:
Toluene inhalation is a common form of drug abuse throughout the world. Acute toluene toxicity causes neurological changes as well as various metabolic alterations. Hypokalemic paralysis and renal failure are life-threatening complications.
OBJECTIVE:
To identify the clinical and metabolic alterations associated with toluene intoxication.
MATERIALS AND METHODS:
We retrospectively analyzed the records of 22 patients that were admitted to a single center's emergency department from 2006 to 2012 with clinical and metabolic alterations due to toluene inhalation.
RESULTS:
Of the 22 patients, 77% were male and mean age was 23.5 years (range: 17-30). The main clinical presentation was weakness associated to severe hypokalemia. Severe metabolic acidosis was found in 20 patients. Renal tubular acidosis was diagnosed in five patients. The patients responded to supportive measures and aggressive potassium repletion. Prognosis was generally good.
CONCLUSION:
Toluene inhalation is associated with various severe metabolic alterations. Treatment guidelines are needed considering the frequency of toluene inhalation in the population.
PMID: 22642292 [PubMed - indexed for MEDLINE]
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Hong Kong Med J. 2005 Feb;11(1):50-3.
Renal tubular acidosis and severe hypophosphataemia due to toluene inhalation.
Tang HL, Chu KH, Cheuk A, Tsang WK, Chan HW, Tong KL.
Source
Division of Nephrology, Department of Medicine and Geriatrics, Princess Margaret Hospital, Laichikok, Kowloon, Hong Kong. pmhrenal@hotmail.com
Abstract
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